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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MEK (MAP2K)-Polfurmetinib
Polfurmetinib

Chemical Structure : Polfurmetinib

CAS No.: 2845151-86-0

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Polfurmetinib (MEK-IN-6)

货号: PC-25083Not For Human Use, Lab Use Only.

Polfurmetinib (Compound II) is a potent, selective mitogen activated protein kinase (MEK) inhibitor, displays an IC50 of 8 nM in human malignant melanoma A375 cells, inhibits ERK1/2 (Thr202/Tyr204) phosphorylation with IC50 of 2 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Polfurmetinib (Compound II) is a potent, selective mitogen activated protein kinase (MEK) inhibitor, displays an IC50 of 8 nM in human malignant melanoma A375 cells, inhibits ERK1/2 (Thr202/Tyr204) phosphorylation with IC50 of 2 nM.

物理化学性质&存储条件

分子量 393.43
分子式 C18H20FN3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione

参考文献

1. Patent WO2022208391 A1.

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