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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MEK (MAP2K)-RO4987655
RO4987655

Chemical Structure : RO4987655

CAS No.: 874101-00-5

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RO4987655 (RO-4987655;RO 4987655;CH-4987655;CH4987655;CH 4987655;RG-7167)

货号: PC-44036Not For Human Use, Lab Use Only.

RO4987655 (CH4987655, RG-7167) is a potent and highly selective small-molecule MEK inhibitor with IC50 of 5.2 nM.

规格 价格 库存 数量
5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥3180 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RO4987655 (CH4987655, RG-7167) is a potent and highly selective small-molecule MEK inhibitor with IC50 of 5.2 nM.
RO4987655 exhibits anti-proliferation IC50s of 1-10 nM for COLO205 (CRC, Braf V600E), HT29 (CRC, Braf V600E), QG56 (NSCLC, HrasQ61L), MIA PaCa-2 (Panc, Kras G12C) cell lines.

物理化学性质&存储条件

分子量 565.2816
分子式 C20H19F3IN3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 40 mg/mL
Chemical Name/SMILES

Benzamide, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(tetrahydro-3-oxo-2H-1,2-oxazin-2-yl)methyl]-

参考文献

1. Isshiki Y, et al. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1795-801.

2. Lee L, et al. Clin Cancer Res. 2009 Dec 1;15(23):7368-74.

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