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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MEK (MAP2K)-G573
G573

Chemical Structure : G573

CAS No.: 22868-35-5

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G573 (G 573, G-573)

货号: PC-62295Not For Human Use, Lab Use Only.

G 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

G573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM.
G573 blocks MEK phosphorylation by BRAF(V600E), and stabilizes the RAF-MEK complex.
G573 inhibits the proliferation of A375 (BRAF V600E) with IC50 of 11 nM, 15-fold less potent for HCT116 (KRAS G13D).

物理化学性质&存储条件

分子量 228.68
分子式 C13H9ClN2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(3-Chlorophenyl)-1H-benzimidazole

参考文献

1. Hatzivassiliou G, et al. Nature. 2013 Sep 12;501(7466):232-6.

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