| Cat. No. |
Product Name |
Information |
| PC-45628 |
Lorediplon
GABAA PAM
|
Lorediplon is a partial positive allosteric GABAA receptor modulator, displays activity at the alpha1-subunit, associated with promoting sleep. |
| PC-45060 |
Basmisanil
GABAA α5 NAM
|
Basmisanil (RG1662) is a potent, selective negative allosteric modulator of GABAA receptor α5-subtype with binding Ki of 5 nM for recombinant human GABAA-α5 receptors. |
| PC-46124 |
Baclofen
GABAB agonist, VDCC inhibitor
|
Baclofen is a derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist. |
| PC-45171 |
(R)-Baclofen
GABAB agonist, VDCC inhibitor
|
(R)-Baclofen (STX-209, Arbaclofen) derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist. |
| PC-22890 |
MP-III-022
α5GABAARs PAM
|
MP-III-022 is a potent, selective positive allosteric modulator of GABAA receptors containing the α5 subunit (α5GABAARs) with Ki value of 55 nM (α5β3γ2S), 15, 6 and 12-fold selectivity over α1, α2 and α3-containing GABAA receptors, respectively. |
| PC-22282 |
Lesogaberan hydrochloride
GABAB agonist
|
Lesogaberan (AZD3355) hydrochloride is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM). |
| PC-22281 |
NS16085
GABAA α2/α3 agonist
|
NS16085 is a potent, selective alpha2/alpha3 subtype-selective GABA(A) receptor positive allosteric modulator, dsplays negligible efficacy at GABAA-α5 receptors. |
| PC-22151 |
SL651498
GABAARa agonist
|
SL651498 is a functional selective agonist of alpha2- and alpha3-containing GABAA receptors with high affinity containing alpha(1) (Ki= 6.8 nM) and alpha2 (Ki =12.3 nM) subunits, and weaker affinity for alpha5-containing GABA(A) receptors (Ki=117 nM). |
| PC-21943 |
MRK-898
GABA A modulator
|
MRK-898 is an orally active GABA(A) receptor modulator, binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. |
| PC-21611 |
DS-II-73
GABAAR modualtor
|
DS-II-73 is a selective α2/3/5-containing GABAA receptor (GABAAR) potentiator with IC50 of 320 nM, 381 nM and 435 nM for α2β3γ2 α3β3γ2 α5β3γ2. |
| PC-42115 |
DMCM hydrochloride
|
A potent benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity. |
| PC-45152 |
Acamprosate calcium
|
A GABA receptor agonist and modulator of glutamatergic systems. |
