AZD7325 | GABAA α2/α3 PAM | Probechem Biochemicals

Chemical Structure : AZD7325

CAS No.: 942437-37-8

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AZD7325 (AZD-7325, AZD 7325)

货号: PC-62090Not For Human Use, Lab Use Only.

AZD7325 is a potent, α2/3 functionally selective, partial GABAA receptor positive allosteric modulator with pKi of 9.51.

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2 mg (Free Sample)	￥280	In stock
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

AZD7325 is a potent, α2/3 functionally selective, partial GABAA receptor positive allosteric modulator with pKi of 9.51.
AZD7325 exerts neutral antagonism at the α1-subunit and partial efficacy at the α2,3-subunits over the α5-subunit.
AZD7325 is expected to reduce the risk for the benzodiazepine like side effects, such as sedation and cognitive effects, and shows potential for the treatment of anxiety.

物理化学性质&存储条件

分子量	354.385
分子式	C19H19FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide

参考文献

1. Chen X, et al. Br J Clin Pharmacol. 2014 Dec;78(6):1298-314.

2. Zhou D, et al. Br J Clin Pharmacol. 2012 Jul;74(1):98-108.

3. Jucaite A, et al. Psychopharmacology (Berl). 2017 Feb;234(4):707-716.

4. Alhambra C, et al. Bioorg Med Chem. 2011 May 1;19(9):2927-38.

AZD7325 (AZD-7325, AZD 7325)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD7325 (AZD-7325, AZD 7325)

生物&药学活性

物理化学性质&存储条件

参考文献

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