NS11394 | GABAA PAM | Probechem Biochemicals

Chemical Structure : NS11394

CAS No.: 951650-22-9

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NS11394 (NS-11394)

货号: PC-42797Not For Human Use, Lab Use Only.

NS11394 is a potent, subtype-selective, orally available GABAA receptor positive modulator with Ki of 0.4, 0.8, 0.5 and 0.1 nM for α1, α2, α3 and α5 subunits together with β3γ2.

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2280	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

NS11394 is a potent, subtype-selective, orally available GABAA receptor positive modulator with Ki of 0.4, 0.8, 0.5 and 0.1 nM for α1, α2, α3 and α5 subunits together with β3γ2.
NS11394 displays 600 to 2000-fold over GABAA-α4 or GABAA-α6 containing receptors.
NS11394 exhibits in vivo anxiolytic efficacy, attenuates spontaneous nociceptive behaviors in response to hindpaw injection of formalin and capsaicin in rats.

物理化学性质&存储条件

分子量	353.4165
分子式	C23H19N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 43 mg/mL
Chemical Name/SMILES	[1,1'-Biphenyl]-2-carbonitrile, 3'-[5-(1-hydroxy-1-methylethyl)-1H-benzimidazol-1-yl]-

参考文献

1. Mirza NR, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):954-68.

2. Munro G, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):969-81.

3. Munro G, et al. Neuropharmacology. 2011 Jul-Aug;61(1-2):121-32.

4. Spröte C, et al. Eur J Pharmacol. 2016 Nov 15;791:655-658.

NS11394 (NS-11394)

生物&药学活性

物理化学性质&存储条件

参考文献

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NS11394 (NS-11394)

生物&药学活性

物理化学性质&存储条件

参考文献

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