| Cat. No. |
Product Name |
Information |
| PC-23662 |
Picrotoxin
GABAA receptor antagonist
|
Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor (GABA AR), binds to the interface pocket on the GABAR, causes overstimulation and induces convulsions. |
| PC-22890 |
MP-III-022
α5GABAARs PAM
|
MP-III-022 is a potent, selective positive allosteric modulator of GABAA receptors containing the α5 subunit (α5GABAARs) with Ki value of 55 nM (α5β3γ2S), 15, 6 and 12-fold selectivity over α1, α2 and α3-containing GABAA receptors, respectively. |
| PC-22282 |
Lesogaberan hydrochloride
GABAB agonist
|
Lesogaberan (AZD3355) hydrochloride is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM). |
| PC-22281 |
NS16085
GABAA α2/α3 agonist
|
NS16085 is a potent, selective alpha2/alpha3 subtype-selective GABA(A) receptor positive allosteric modulator, dsplays negligible efficacy at GABAA-α5 receptors. |
| PC-22151 |
SL651498
GABAARa agonist
|
SL651498 is a functional selective agonist of alpha2- and alpha3-containing GABAA receptors with high affinity containing alpha(1) (Ki= 6.8 nM) and alpha2 (Ki =12.3 nM) subunits, and weaker affinity for alpha5-containing GABA(A) receptors (Ki=117 nM). |
| PC-21611 |
DS-II-73
GABAAR modualtor
|
DS-II-73 is a selective α2/3/5-containing GABAA receptor (GABAAR) potentiator with IC50 of 320 nM, 381 nM and 435 nM for α2β3γ2 α3β3γ2 α5β3γ2. |
| PC-42115 |
DMCM hydrochloride
|
A potent benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity. |
| PC-45152 |
Acamprosate calcium
|
A GABA receptor agonist and modulator of glutamatergic systems. |
| PC-45172 |
(R)-Baclofen hydrochloride
|
A derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist. |
| PC-42068 |
Pipequaline
|
A clinically-effective anxiolytic that acts as a non-selective partial agonist of benzodiazepine receptor. |
