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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-GABA Receptor-MP-III-022
MP-III-022

Chemical Structure : MP-III-022

CAS No.: 2133456-81-0

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MP-III-022

货号: PC-22890Not For Human Use, Lab Use Only.

MP-III-022 is a potent, selective positive allosteric modulator of GABAA receptors containing the α5 subunit (α5GABAARs) with Ki value of 55 nM (α5β3γ2S), 15, 6 and 12-fold selectivity over α1, α2 and α3-containing GABAA receptors, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MP-III-022 is a potent, selective positive allosteric modulator of GABAA receptors containing the α5 subunit (α5GABAARs) with Ki value of 55 nM (α5β3γ2S), 15, 6 and 12-fold selectivity over α1, α2 and α3-containing GABAA receptors, respectively.

物理化学性质&存储条件

分子量 372.40
分子式 C22H17FN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-8-ethynyl-6-(2-fluorophenyl)-N,4-dimethyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxamide

参考文献

1. Stamenić TT, et al. Eur J Pharmacol. 2016 Nov 15;791:433-443.

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