Lesogaberan hydrochloride | GABAB agonist | Probechem Biochemicals

Chemical Structure : Lesogaberan hydrochloride

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Lesogaberan hydrochloride (AZD3355 hydrochloride)

货号: PC-22282Not For Human Use, Lab Use Only.

Lesogaberan (AZD3355) hydrochloride is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM).

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生物&药学活性

Lesogaberan (AZD3355) hydrochloride is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM).
Lesogaberan (AZD3355) potently stimulates recombinant human GABAB receptors and inhibits transient lower esophageal sphincter relaxation (TLESR) through a peripheral mode of action in vivo, shows potential for treatment of GERD.

物理化学性质&存储条件

分子量	177.54
分子式	C3H10ClFNO2P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	P-[(2R)-3-amino-2-fluoropropyl]Phosphinic acid hydrochloride

参考文献

1. Boeckxstaens GE, et al. Gut. 2011 Sep;60(9):1182-8.

2. Alstermark C, et al. J Med Chem. 2008 Jul 24;51(14):4315-20.

Lesogaberan hydrochloride (AZD3355 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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Lesogaberan hydrochloride (AZD3355 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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