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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-GABA Receptor-SL651498
SL651498

Chemical Structure : SL651498

CAS No.: 205881-86-3

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SL651498 (SL-651498)

货号: PC-22151Not For Human Use, Lab Use Only.

SL651498 is a functional selective agonist of alpha2- and alpha3-containing GABAA receptors with high affinity containing alpha(1) (Ki= 6.8 nM) and alpha2 (Ki =12.3 nM) subunits, and weaker affinity for alpha5-containing GABA(A) receptors (Ki=117 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SL651498 is a functional selective agonist of alpha2- and alpha3-containing GABAA receptors with high affinity containing alpha(1) (Ki= 6.8 nM) and alpha2 (Ki =12.3 nM) subunits, and weaker affinity for alpha5-containing GABA(A) receptors (Ki=117 nM).
SL651498 is a full agonist at recombinant rat GABA(A) receptors containing alpha2 and alpha3 subunits and as a partial agonist at recombinant GABA(A) receptors expressing alpha1 and alpha5 subunits.
SL651498 elicited anxiolytic-like activity similar to that of diazepam [minimal effective dose (MED): 1-10 mg/kg, i.p.] in three conflict models, in the elevated plus-maze, the light/dark test, and the defense test battery in rats and mice.

物理化学性质&存储条件

分子量 389.43
分子式 C23H20FN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-fluoro-2,9-dihydro-9-methyl-2-phenyl-4-(1-pyrrolidinylcarbonyl)-1H-pyrido[3,4-b]indol-1-one

参考文献

1. Griebel G, et al. J Pharmacol Exp Ther. 2001 Aug;298(2):753-68.

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