DS-II-73

Chemical Structure : DS-II-73

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货号: PC-21611Not For Human Use, Lab Use Only.

DS-II-73 is a selective α2/3/5-containing GABAA receptor (GABAAR) potentiator with IC50 of 320 nM, 381 nM and 435 nM for α2β3γ2 α3β3γ2 α5β3γ2.

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生物&药学活性

DS-II-73 is a selective α2/3/5-containing GABAA receptor (GABAAR) potentiator with IC50 of 320 nM, 381 nM and 435 nM for α2β3γ2 α3β3γ2 α5β3γ2.
DS-II-73 shows binding to the GABAAR with little ancillary activity.
DS-II-73 displays IC50 values for inhibition of [3H]-flunitrazepam binding with α2 < α3 < α5 < α1.
DS-II-73 shows robust and significant antiseizure effects.

物理化学性质&存储条件

分子量	406.24
分子式	C19H12BrN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole

参考文献

1. Dishary Sharmin, et al. ACS Chem Neurosci. 2024 Jan 4. doi: 10.1021/acschemneuro.3c00555.

DS-II-73

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物理化学性质&存储条件

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DS-II-73

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物理化学性质&存储条件

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