Pagoclone | GABAA agonist | Probechem Biochemicals

Chemical Structure : Pagoclone

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Pagoclone ((+)-RP-59037, IP-456, RP-62955, CI-1043)

货号: PC-42414Not For Human Use, Lab Use Only.

Pagoclone ((+)-RP-59037, IP-456) is a potent, orally active GABAA receptor agonist with high affinity (0.7-9.1nM) to the benzodiazepine binding site of GABAA receptors containing either an α1, α2, α3 or α5 subunit.

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生物&药学活性

Pagoclone ((+)-RP-59037, IP-456) is a potent, orally active GABAA receptor agonist with high affinity (0.7-9.1nM) to the benzodiazepine binding site of GABAA receptors containing either an α1, α2, α3 or α5 subunit.
Pagoclone ((+)-RP-59037, IP-456) exhibits significant anxiolytic-like activity in vivo.

物理化学性质&存储条件

分子量	407.89268
分子式	C23H22ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Isoindol-1-one, 2-(7-chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-, (+)-

参考文献

1. Atack JR. Expert Opin Investig Drugs. 2005 May;14(5):601-18.

2. Atack JR, et al. Neuropharmacology. 2006 May;50(6):677-89.

3. Caveney AF, et al. Neuropsychiatr Dis Treat. 2008 Feb;4(1):277-82.

Pagoclone ((+)-RP-59037, IP-456, RP-62955, CI-1043)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pagoclone ((+)-RP-59037, IP-456, RP-62955, CI-1043)

生物&药学活性

物理化学性质&存储条件

参考文献

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