MK-0343 | GABAA agonist | Probechem Biochemicals

Chemical Structure : MK-0343

CAS No.: 233275-76-8

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MK-0343 (MRK-409, MK0343)

货号: PC-62091Not For Human Use, Lab Use Only.

MK-0343 (MRK-409) is a potent, α2/3 subtype selective, partial GABAA receptor agonist, shows greater agonist efficacy at the α3 over α1 subtypes.

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生物&药学活性

MK-0343 (MRK-409) is a potent, α2/3 subtype selective, partial GABAA receptor agonist, shows greater agonist efficacy at the α3 over α1 subtypes.
MK-0343 readily penetrates the brain in rats and occupies the benzodiazepine site of GABA(A) receptors with an Occ(50) of 2.2 mg/kg p.o. and a corresponding plasma EC50 of 115 ng/mL.
MK-0343 produces anxiolytic-like activity in rodent and primate unconditioned and conditioned models of anxiety.

物理化学性质&存储条件

分子量	397.39
分子式	C19H17F2N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine

参考文献

1. Atack JR, et al. J Psychopharmacol. 2011 Mar;25(3):314-28.

2. de Haas SL, et al. J Psychopharmacol. 2008 Jan;22(1):24-32.

MK-0343 (MRK-409, MK0343)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-0343 (MRK-409, MK0343)

生物&药学活性

物理化学性质&存储条件

参考文献

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