Indiplon | GABAA PAM | Probechem Biochemicals

Chemical Structure : Indiplon

CAS No.: 325715-02-4

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Indiplon (NBI-34060, NBI 34060)

货号: PC-45592Not For Human Use, Lab Use Only.

Indiplon (NBI-34060) is a potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site (Ki values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively).

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生物&药学活性

Indiplon (NBI-34060) is a potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site (Ki values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively).
Indiplon potentiates the GABA-activated chloride current in recombinant GABA(A) receptors in a dose-dependent and reversible manner in 293 cells, 10-fold selective for α1 subunit-containing receptors over GABA(A) receptors containing α2, α3, or α5 subunits.

物理化学性质&存储条件

分子量	376.4316
分子式	C20H16N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, N-methyl-N-[3-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-

参考文献

1. Lankford A. Neuropsychiatr Dis Treat. 2007 Dec;3(6):765-73.

2. Marrs JC. Ann Pharmacother. 2008 Jul;42(7):1070-9.

3. Petroski RE, et al. J Pharmacol Exp Ther. 2006 Apr;317(1):369-77.

Indiplon (NBI-34060, NBI 34060)

生物&药学活性

物理化学性质&存储条件

参考文献

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Indiplon (NBI-34060, NBI 34060)

生物&药学活性

物理化学性质&存储条件

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