| Cat. No. |
Product Name |
Information |
| PC-42532 |
BMS-690514
EGFR/VEGFR inhibitor
|
BMS-690514 is a potent pan EGFR/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively. |
| PC-45785 |
Tyrphostin AG 879
HER2 inhibitor, TrkA inhibitor
|
Tyrphostin AG 879 (AG879) potent HER2/ErbB2 inhibitor with IC50 of 1 uM, also selecitvely inhibits TrKA phosphorylation with IC50 of 10 uM, but not TrKB and TrKC. |
| PC-42386 |
RG13022
EGFR inhibitor
|
RG13022 is a potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 5 uM in cell-free assays. |
| PC-42383 |
RG14620
EGFR inhibitor
|
RG14620 is a potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 4 uM in cell-free assays. |
| PC-42546 |
AV-412 free base
EGFR inhibitor
|
AV-412 free base (MP412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively. |
| PC-42545 |
AV-412
EGFR inhibitor
|
AV-412 (MP 412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively. |
| PC-45479 |
PD158780
EGFR inhibitor
|
PD158780 is a highly potent, selective, ATP binding site inhibitor of EGFR with IC50 of 8 nM. |
| PC-45995 |
Mutated EGFR-IN-1
EGFR inhibitor
|
Mutated EGFR-IN-1 is an analogue of AZD9291 that is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. |
| PC-27403 |
FHND9041
EGFR T790M inhibitor
|
Adonertinib (FHND9041) is a third-generation, irreversible EGFR T790M mutation-selective inhibitor, selectively inhibitsphosphorylation of EGFR mutant kinase and the activation of its downstream key signaling molecules, Akt and Erk, thereby inhibiting the proliferation of tumor cells with EGFR T790M resistance or sensitive mutations and inducing apoptosis of tumor cells. |
| PC-27288 |
ZW-49
EGFR inhibitor
|
ZW-49 is a potent, selective and covalent inhibitor of all subgroups of EGFR mutations with IC50 of 1.5 nM (EGFR L858R/T790M), potently inhibits all subgroups of EGFR mutations with selectivity over wild-type EGFR and other target families. |
| PC-26663 |
SH-1092
EGFR inhibitor
|
SH-1092 is a potent third generation EGFR inhibitor with IC50 of 0.96 nM and 6.1 nM for EGFR(T790M/L858R) and EGFR(WT) respectively. |
| PC-26083 |
JIN-A02
EGFR C797S inhibitor
|
JIN-A02 is a potent, mutant-selective, orally available fourth-generation EGFR tyrosine kinase inhibitor (EGFR-TKI), overcomes C797S-mediated resistance. |
