| Cat. No. |
Product Name |
Information |
| PC-24971 |
Pebezertinib
EGFR inhibitor
|
Pebezertinib (BLU-451, LNG-451) is a potent, CNS-penetrant, wild-type EGFR sparing inhibitor of EGFR exon 20 insertion mutations, as well as atypical (G719C, G719S, L861Q) and common EGFR mutants. |
| PC-24940 |
Genistein
Hsp90β inhibitor
|
Genistein (NPI 031L) is a soy isoflavone and multiple tyrosine kinases (e.g., EGFR, MKK4 (IC50=400 nM)) inhibitor, Genistein is a chemotherapeutic agent against different types of cancer. |
| PC-24922 |
EGFR-targeting peptide GE11
EGFR ligand
|
EGFR-targeting peptide GE11 is an epidermal growth factor receptor (EGFR)-specific ligand for active targeting of EGFR-overexpressing cancer cells, Conjugation of GE11 peptides to liposomal constructs enhances anti-tumor efficacies and specificities in laryngeal cancer cells. |
| PC-24741 |
HS-10375
EGFR C797S inhibitor
|
HS-10375 is a potent, selective EGFR C797S tyrosine kinase inhibitor, shows potent inhibitory activity against EGFR C797S mutations (Del19/T790M/C797S, L858R/T790M/C797S, Del19/C797S, and L858R/C797S), and common and/or T790M mutations (Del19, T790M, L858R/T790M, and Del19/T790M) with IC50 < 1.5 nM. |
| PC-24584 |
ELF3-MED23 interaction inhibitor YK1
ELF3-MED23 inhibitor
|
YK1 is a potent and selective PPI inhibitor for ELF3-MED23 with IC50 of 1.18 uM, 95 % inhibition at 10 uM, attenuates the HER2-mediated oncogenic signaling cascades. |
| PC-24432 |
ErbB4 receptor agonist E4A
ErbB4 agonist
|
ErbB4 receptor agonist E4A is a small molecule ErbB4 receptor agonist, activates ErbB4 receptor and prevents neuronal senescence induced by D-Galactose through inhibition of the ferroptosis pathway. |
| PC-24172 |
YK-029A
mutant EGFR inhibitor
|
Pruvonertinib (YK-029A) is potent, wild-type sparing and mutant-selective inhibitor of EGFR T790 M and exon 20 insertion mutations with IC50 of 0.37 nM (EGFR L858R/T790 M), 29-fold selective over EGFR wt. |
| PC-24129 |
Emupertinib
EGFR inhibitor
|
Emupertinib is a potent EGFR inhibitor with IC50 values of <0.3 nM, 0.52 nM, 0.5 nM, 0.69 nM and 0.92 nM for EGFR (d746-750/T790M/C779S), EGFR (L858R/T790M/C797S), EGFR (d746-750/C797S), EGFR (L858R/C797S), and EGFR (wild-type), respectively. |
| PC-24110 |
Andamertinib
EGFR inhibitor
|
Andamertinib (PLB1004, PLB-1004) is a potent, selective and irreversible inhibitor of EGFR exon 20 insertion mutations with IC50 values ranging from 25.67-316.6 nM. |
| PC-24040 |
DA-0157
EGFR/ALK inhibitor
|
DA-0157 (DAJH-1050766) is a potent, dual inhibitor targeting EGFR C797S mutation, ALK-positive, and EGFR/ALK co-mutations with IC50 of 6.9 nM, 5.5 nM and 7.4 nM for EGFRDel19/T790M/C797S, ALK-WT and ALK-L1196M in Ba/F3 cell assays, respectively. |
| PC-23954 |
AZ14245445
EGFR Ex20Ins inhibitor
|
AZ14245445 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.9 in cellular SVD, (EGFR D770_N771insSVD) assays. |
| PC-23953 |
AZ14240475
EGFR Ex20Ins inhibitor
|
AZ14240475 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.6 in cellular SVD, (EGFR D770_N771insSVD) assays. |
