AV-412 |CAS:451493-31-5 Probechem Biochemicals

Chemical Structure : AV-412

CAS No.: 451493-31-5

加入收藏

AV-412 (MP-412;AV412;AV 412;MP412;MP 412)

货号: PC-42545Not For Human Use, Lab Use Only.

AV-412 (MP 412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AV-412 (MP 412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively.
AV-412 also inhibits Abl (IC50=41 nM), weakly inhibits Flt3 and Src.
AV-412 inhibits autophosphorylation of EGFR and ErbB2 with IC50 of 43 and 282 nM.
AV-412 inhibits EGF-dependent cell proliferation with IC50 of 100 nM; active in cancer xenograft models.

物理化学性质&存储条件

分子量	851.4055
分子式	C41H44ClFN6O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-methylbenzenesulfonate (1:2)

参考文献

1. Suzuki T, et al. Cancer Sci. 2007 Dec;98(12):1977-84.

2. Suzuki T, et al. Cancer Sci. 2009 Aug;100(8):1526-31.

3. Zhou Y, et al. Nat Biotechnol. 2010 Jan;28(1):71-8.

AV-412 (MP-412;AV412;AV 412;MP412;MP 412)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AV-412 (MP-412;AV412;AV 412;MP412;MP 412)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.