PD158780 |CAS:171179-06-9 Probechem Biochemicals

Chemical Structure : PD158780

CAS No.: 171179-06-9

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PD158780 (PD-158780)

货号: PC-45479Not For Human Use, Lab Use Only.

PD158780 is a highly potent, selective, ATP binding site inhibitor of EGFR with IC50 of 8 nM.

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25 mg	￥1980	In stock
50 mg	￥3280	In stock
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生物&药学活性

PD158780 is a highly potent, selective, ATP binding site inhibitor of EGFR with IC50 of 8 nM.
PD158780 inhibits EGFR autophosphorylation in A431 human epidermoid carcinoma cells (IC50=15 nM).
PD158780 potently inhibits the LPA-stimulated MKK1/2 activation and EGFR phosphorylation in HeLa cells.
PD158780 also inhibits the kinase activity of ACK-1 in vitro (IC50=200 nM), inhibits the growth of v-Ha-Ras-transformed NIH 3T3 cells.

物理化学性质&存储条件

分子量	330.1826
分子式	C14H12BrN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrido[3,4-d]pyrimidine-4,6-diamine, N4-(3-bromophenyl)-N6-methyl-

参考文献

1. Rewcastle GW, et al. J Med Chem. 1996 Apr 26;39(9):1823-35.

2. Cunnick JM, et al. J Biol Chem. 1998 Jun 5;273(23):14468-75.

3. Nur-E-Kamal A, et al. Mol Cancer Res. 2005 May;3(5):297-305.

PD158780 (PD-158780)

生物&药学活性

物理化学性质&存储条件

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PD158780 (PD-158780)

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物理化学性质&存储条件

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