ErbB4 receptor agonist E4A is a small molecule ErbB4 receptor agonist, activates ErbB4 receptor and prevents neuronal senescence induced by D-Galactose through inhibition of the ferroptosis pathway.
ErbB4 receptor agonist E4A is a small molecule ErbB4 receptor agonist, activates ErbB4 receptor and prevents neuronal senescence induced by D-Galactose through inhibition of the ferroptosis pathway. E4A significantly ameliorated the behavioral deficits induced by D-gal in mice, demonstrating an effect comparable to that of melatonin, a natural inhibitor of in vivo senescence and ferroptosis. E4A mitigated D-gal-induced aging in hippocampal neurons of mice. E4A markedly ameliorated Erastin-induced ferroptosis in mouse hippocampal neuronal cells. E4A upregulated the expression of dedicator of cytokinesis 3 (DOCK3) and Sirtuin 3 (SIRT3) and mitigated mitochondrial and synaptic dysfunction within the hippocampus of PS-MPs-exposed mice. E4A also diminished the activation of the TLR4-NF-κB-NLRP3 signaling pathway, consequently reducing neuroinflammation.
物理化学性质&存储条件
分子量
267.08
分子式
C11H7BrO3
外观性状
Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-bromo-1-hydroxy-2-naphthoic acid
参考文献
1. Dao JJ, et al. Front Pharmacol. 2025 Jan 31;16:1528604.
2. Liu C, et al. J Neuroinflammation. 2025 Mar 15;22(1):86.
