| Cat. No. |
Product Name |
Information |
| PC-42819 |
WZ-3146
EGFR inhibitor
|
WZ-3146 is a potent, mutant-selective EGFR kinase inhibitor with IC50 of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746-A750, EGFRE746-A750/T790M and wt EGFR, respectively. |
| PC-42818 |
AG490
Multikinase inhibitor
|
AG-490 (Tyrphostin AG 490) is a multi-targeted tyrphostin family of tyrosine kinase inhibitor, inhibits EGF receptor tyrosine kinase with IC50 of 2 and 13.5 uM for EGFR and ErbB2, also inhibits JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways. |
| PC-63158 |
AZ5104
EGFR inhibitor
|
AZ5104 (AZ-5104) is the active metabolite of AZD 9291 (Osimertinib), which is an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC50=15-17 nM) that spares the wild-type form of the receptor (IC50=480 nM). |
| PC-62999 |
BIBU1361 dihydrochloride
EGFR inhibitor
|
BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM). |
| PC-62998 |
BIBU1361
EGFR inhibitor
|
BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM). |
| PC-62304 |
HER2-IN-3
HER2 inhibitor
|
HER2-IN-3 is a type I HER2 inhibitor that has a similar profile to HER2-IN-2, inhibits the active HER2/HER3 heterodimer in multiple oncogenic settings. |
| PC-62303 |
HER2-IN-2
HER2 inhibitor
|
HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases. |
| PC-62121 |
Theliatinib
EGFR inhibitor
|
Theliatinib (HMPL309) is a highly selective, potent, ATP-competitive inhibitor of EGFR with IC50 of 3 nM/22 nM for EGFR/EGFRT790M/L858R mutant, respectively. |
| PC-61769 |
SKLB188
EGFR inhibitor
|
SKLB188 is a small molecule multikinase inhibitor and potently inhibits EGFR with IC50 of 5 nM. |
| PC-61597 |
CK-101
|
CK-101 (Olafertinib, RX-518) is a novel potent, mutant-selective, irreversible, orally available EGFR inhibitor, overcomes T790M-mediated resistance in NSCLC. |
| PC-61450 |
Avitinib maleate
EGFR inhibitor
|
Avitinib maleate (AC-0010MA, AC0010 maleate) is an orally available, irreversible, and mutant-selective EGFR inhibitor with IC50 of 0.18 nM against EGFR L858R/T790M. |
| PC-61449 |
Avitinib
EGFR inhibitor
|
Avitinib (Abivertinib, AC-0010, AC0010) is an orally available, irreversible, and mutant-selective EGFR inhibitor with IC50 of 0.18 nM against EGFR L858R/T790M. |
