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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-PD153035 hydrochloride
PD153035 hydrochloride

Chemical Structure : PD153035 hydrochloride

CAS No.: 183322-45-4

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PD153035 hydrochloride (ZM 252868;AG 1517;Tyrphostin AG 1517;SU 5271;PD-153035;PD 153035)

货号: PC-42828Not For Human Use, Lab Use Only.

PD153035 (ZM 252868, AG 1517, Tyrphostin AG 1517, SU 5271) is a highly potent, specific, ATP-competitive EGFR inhibitor with IC50 of 0.025 nM.

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25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥3180 In stock
500 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PD153035 (ZM 252868, AG 1517, Tyrphostin AG 1517, SU 5271) is a highly potent, specific, ATP-competitive EGFR inhibitor with IC50 of 0.025 nM; inhibits EGF-dependent EGF receptor phosphorylation and suppresses the proliferation and clonogenicity of a wide panel of EGF receptor-overexpressing human cancer cell lines (IC50<1 uM); rapidly suppresses phosphorylation of the EGF receptor in A431 human epidermoid tumors grown as xenografts in immunodeficient nude mice.

物理化学性质&存储条件

分子量 396.6662
分子式 C16H15BrClN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO
Chemical Name/SMILES

4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochloride (1:1)

参考文献

1. Bridges AJ, et al. J Med Chem. 1996 Jan 5;39(1):267-76.

2. Bos M, et al. Clin Cancer Res. 1997 Nov;3(11):2099-106.

3. Fry DW, et al. Science. 1994 Aug 19;265(5175):1093-5.

4. Kunkel MW, et al. Invest New Drugs. 1996;13(4):295-302.

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