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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-WZ8040
WZ8040

Chemical Structure : WZ8040

CAS No.: 1214265-57-2

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WZ8040 (WZ-8040;WZ 8040)

货号: PC-42843Not For Human Use, Lab Use Only.

WZ8040 is a potent, mutant-selective, irreversible EGFR T790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I) and is 100-fold less potent against wild-type EGFR.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

WZ8040 is a potent, mutant-selective, irreversible EGFR T790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I) and is 100-fold less potent against wild-type EGFR.
WZ8040 potently inhibits the growth of HCC827 (EGFR Del E746_A750), PC9 (EGFR Del E746_A750), H3255 (EGFR L858R), H1975 (EGFR L858R/T790M), and PC9 GR (EGFR Del E746_A750/T790M) with IC50 of 1 nM, 6 nM, 66 nM, 9 nM, and 8 nM, respectively.

物理化学性质&存储条件

分子量 481.0129
分子式 C24H25ClN6OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-

参考文献

1. Zhou W, et al. Nature. 2009 Dec 24;462(7276):1070-4.

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