| Cat. No. |
Product Name |
Information |
| PC-45813 |
Neratinib
HER2/EGFR inhibitor
|
Neratinib (HKI-272) is a potent, highly selective, irreversible HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays. |
| PC-42532 |
BMS-690514
EGFR/VEGFR inhibitor
|
BMS-690514 is a potent pan EGFR/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively. |
| PC-45785 |
Tyrphostin AG 879
HER2 inhibitor, TrkA inhibitor
|
Tyrphostin AG 879 (AG879) potent HER2/ErbB2 inhibitor with IC50 of 1 uM, also selecitvely inhibits TrKA phosphorylation with IC50 of 10 uM, but not TrKB and TrKC. |
| PC-42386 |
RG13022
EGFR inhibitor
|
RG13022 is a potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 5 uM in cell-free assays. |
| PC-42383 |
RG14620
EGFR inhibitor
|
RG14620 is a potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 4 uM in cell-free assays. |
| PC-42546 |
AV-412 free base
EGFR inhibitor
|
AV-412 free base (MP412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively. |
| PC-42545 |
AV-412
EGFR inhibitor
|
AV-412 (MP 412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively. |
| PC-45479 |
PD158780
EGFR inhibitor
|
PD158780 is a highly potent, selective, ATP binding site inhibitor of EGFR with IC50 of 8 nM. |
| PC-45995 |
Mutated EGFR-IN-1
EGFR inhibitor
|
Mutated EGFR-IN-1 is an analogue of AZD9291 that is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. |
| PC-25853 |
NSC228155
EGFR activator, CREB-CBP inhibitor
|
NSC228155 (NSC 228155) is a potent inhibitor of CREB-CBP interaction (IC50=0.36 uM) taregting interaction of kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, also is an activator of EGFR, binds to the extracellular region of EGFR and enhances tyrosine phosphorylation of EGFR. |
| PC-25509 |
Tarloxotinib
pan-HER inhibitor
|
Tarloxotinib (TH-4000) is a hypoxia-activated pan-HER inhibitor, generates the active form TH-4000Effector (TH-4000E) under hypoxic condition, TH-4000E selectively inhibits EGFR, HER2 and HER4 with IC50 of <1 nM. |
| PC-25435 |
AZ14289671
EGFR inhibitor
|
AZ14289671 is a potent, highly selective and blood-brain barrier penetrant irreversible inhibitor of EGFR exon 20 insertion (EGFRExon20Ins) mutations, inhibits EGFR phosphorylation across EGFRExon20Ins with IC50 of 17-41 nM, spares wild-type EGFR. |
