Rociletinib (CO-1686) hydrobromide |CAS:1446700-26-0 Probechem Biochemicals

Chemical Structure : CO-1686 hydrobromide

CAS No.: 1446700-26-0

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CO-1686 hydrobromide (Rociletinib hydrobromide, AVL-301 hydrobromide, CNX-419 hydrobromide)

货号: PC-44667Not For Human Use, Lab Use Only.

Rociletinib (CO-1686) hydrobromide is a potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M.

规格	价格	库存
25 mg	￥880	In stock
50 mg	￥1280	In stock
100 mg	￥1980	In stock
250 mg		Get quote

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生物&药学活性

Rociletinib (CO-1686) hydrobromide is a potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M.
Rociletinib (CO-1686) shows 22-fold selective over WT EGFR; EGFR del19, T790M, L858R/T790M and L858R mutant kinases demonstrates the highest degree of inhibition at 0.1 uM; orally bioavailable.

物理化学性质&存储条件

分子量	636.4634
分子式	C27H29BrF3N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 59 mg/mL
Chemical Name/SMILES	2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-, hydrobromide (1:1)

参考文献

1. Walter AO, et al. Cancer Discov. 2013 Dec;3(12):1404-15.

2. Tjin Tham Sjin R, et al. Mol Cancer Ther. 2014 Jun;13(6):1468-79.

3. Sequist LV, et al. N Engl J Med. 2015 Apr 30;372(18):1700-9.

CO-1686 hydrobromide (Rociletinib hydrobromide, AVL-301 hydrobromide, CNX-419 hydrobromide)

生物&药学活性

物理化学性质&存储条件

参考文献

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CO-1686 hydrobromide (Rociletinib hydrobromide, AVL-301 hydrobromide, CNX-419 hydrobromide)

生物&药学活性

物理化学性质&存储条件

参考文献

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