BMS-690514 |CAS:859853-30-8 Probechem Biochemicals

Chemical Structure : BMS-690514

CAS No.: 859853-30-8

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BMS-690514 (BMS690514;BMS 690514)

货号: PC-42532Not For Human Use, Lab Use Only.

BMS-690514 is a potent pan EGFR/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
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BMS-690514 is a potent pan EGFR/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively.
BMS-690514 exerts antiproliferative and proapoptotic effects on NSCLC cell lines, with prominent efficacy on H1975 cells expressing the T790M mutation; induces G1 cell cycle arrest.

物理化学性质&存储条件

分子量	368.4329
分子式	C19H24N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Piperidinol, 4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]-, (3R,4R)-

参考文献

1. de La Motte Rouge T, et al. Cancer Res. 2007 Jul 1;67(13):6253-62.

2. Wong TW, et al. Clin Cancer Res. 2011 Jun 15;17(12):4031-41.

3. Loriot Y, et al. Br J Cancer. 2010 Jul 27;103(3):347-53.

BMS-690514 (BMS690514;BMS 690514)

生物&药学活性

物理化学性质&存储条件

参考文献

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BMS-690514 (BMS690514;BMS 690514)

生物&药学活性

物理化学性质&存储条件

参考文献

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