Tyrphostin AG 879 | HER2 inhibitor, TrkA inhibitor | Probechem Biochemicals

Chemical Structure : Tyrphostin AG 879

CAS No.: 148741-30-4

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Tyrphostin AG 879 (AG-879, AG879)

货号: PC-45785Not For Human Use, Lab Use Only.

Tyrphostin AG 879 (AG879) potent HER2/ErbB2 inhibitor with IC50 of 1 uM, also selecitvely inhibits TrKA phosphorylation with IC50 of 10 uM, but not TrKB and TrKC.

规格	价格	库存
5 mg (Free Sample)	￥280	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote

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生物&药学活性

Tyrphostin AG 879 (AG879) potent HER2/ErbB2 inhibitor with IC50 of 1 uM, also selecitvely inhibits TrKA phosphorylation with IC50 of 10 uM, but not TrKB and TrKC.
Tyrphostin AG 879 is 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.
Tyrphostin AG 879 inhibits growth of FET6αS26X cells in a concentration-dependent manner.
Tyrphostin AG 879 blocks the activation of PAK1 and suppresses RAS-induced malignant transformation of NIH 3T3 cells.
Tyrphostin AG 879 reduces the size of the growing sarcomas in the nude mice carrying v-Ha-RAS transformed NIH 3T3 cells.

物理化学性质&存储条件

分子量	316.461
分子式	C18H24N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)-

参考文献

1. Ohmichi M, et al. Biochemistry. 1993 May 4;32(17):4650-8.

2. Zhou Y, et al. Cancer Res. 2005 Jul 1;65(13):5848-56.

3. He H, et al. Cancer J. 2001, 7(3), 191-202.

Tyrphostin AG 879 (AG-879, AG879)

生物&药学活性

物理化学性质&存储条件

参考文献

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Tyrphostin AG 879 (AG-879, AG879)

生物&药学活性

物理化学性质&存储条件

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