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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-RG13022
RG13022

Chemical Structure : RG13022

CAS No.: 136831-48-6

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RG13022 (Tyrphostin RG13022, RG-13022)

货号: PC-42386Not For Human Use, Lab Use Only.

RG13022 is a potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 5 uM in cell-free assays.

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5 mg ￥480 In stock
10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RG13022 is a potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 5 uM in cell-free assays.
RG13022 suppresses not only EGF-stimulated cancer cell proliferation in vitro but also tumor growth in nude mice.
RG13022 inhibits cell proliferation of gastric cancer cell lines.

物理化学性质&存储条件

分子量 266.29456
分子式 C16H14N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 10 mM
Chemical Name/SMILES

3-Pyridineacetonitrile, α-[(3,4-dimethoxyphenyl)methylene]-

参考文献

1. Yoneda T, et al. Cancer Res. 1991 Aug 15;51(16):4430-5.

2. McLeod HL, et al. Br J Cancer. 1996 Dec;74(11):1714-8.

3. McLaughlin M, et al. Int J Oncol. 1996 Mar;8(3):589-96.

4. Xian W, et al. Cell Growth Differ. 1995 Nov;6(11):1447-55.

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