欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-AZD3759
AZD3759

Chemical Structure : AZD3759

CAS No.: 1626387-80-1

加入收藏

AZD3759 (AZD-3759, Zorifertinib)

货号: PC-45549Not For Human Use, Lab Use Only.

AZD3759 (Zorifertinib) is a potent, orally active, BBB-penetrating EGFR inhibitor (IC50=7.2 nM, L858R pEGFR).

规格 价格 库存 数量
25 mg ￥980 In stock
50 mg ￥1380 In stock
100 mg ￥2180 In stock
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD3759 (Zorifertinib) is a potent, orally active, BBB-penetrating EGFR inhibitor (IC50=7.2 nM, L858R pEGFR).
AZD3759 fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue; causes tumor regression in subcutaneous xenograft, leptomeningeal metastasis (LM), and brain metastasis (BM) lung cancer models and prevents the development of BM in nude mice.

物理化学性质&存储条件

分子量 459.9011
分子式 C22H23ClFN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-

参考文献

1. Zeng Q, et al. J Med Chem. 2015 Oct 22;58(20):8200-15.

2. Yang Z, et al. Sci Transl Med. 2016 Dec 7;8(368):368ra172.

3. Tan CS, et al. Lung Cancer. 2016 Mar;93:59-68.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: