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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-WZ-3146
WZ-3146

Chemical Structure : WZ-3146

CAS No.: 1214265-56-1

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WZ-3146 (WZ3146;WZ 3146)

货号: PC-42819Not For Human Use, Lab Use Only.

WZ-3146 is a potent, mutant-selective EGFR kinase inhibitor with IC50 of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746-A750, EGFRE746-A750/T790M and wt EGFR, respectively.

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1 mg (Free Sample) ￥280 In stock
5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

WZ-3146 is a potent, mutant-selective EGFR kinase inhibitor with IC50 of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746-A750, EGFRE746-A750/T790M and wt EGFR, respectively.
WZ-3146 suppresses the growth of EGFR T790M containing cell lines and inhibit EGFR phosphorylation.

物理化学性质&存储条件

分子量 464.9473
分子式 C24H25ClN6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-

参考文献

1. Zhou W, et al. Nature. 2009 Dec 24;462(7276):1070-4.

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