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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-NSC228155
NSC228155

Chemical Structure : NSC228155

CAS No.: 113104-25-9

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NSC228155 (NSC 228155)

货号: PC-25853Not For Human Use, Lab Use Only.

NSC228155 (NSC 228155) is a potent inhibitor of CREB-CBP interaction (IC50=0.36 uM) taregting interaction of kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, also is an activator of EGFR, binds to the extracellular region of EGFR and enhances tyrosine phosphorylation of EGFR.

规格 价格 库存 数量
10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC228155 (NSC 228155) is a potent inhibitor of CREB-CBP interaction (IC50=0.36 uM) taregting interaction of kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, also is an activator of EGFR, binds to the extracellular region of EGFR and enhances tyrosine phosphorylation of EGFR.
NSC228155 inhibited the pertussis AB5 holotoxin-catalyzed ADP-ribosylation of Gαi in living human cells with IC50 of 2.4 uM.
NSC228155 attenuated tumor suppressor function of ABHD11‑AS1 in in colorectal cancer (CRC) cells.

物理化学性质&存储条件

分子量 290.25
分子式 C11H6N4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((7-Nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)pyridine 1-oxide

参考文献

1. Xie F, et al. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5371-5.

2. Ashok Y, et al. ACS Infect Dis. 2020 Apr 10;6(4):588-602.

3. Sakanyan V, et al. Sci Rep. 2016 Feb 17;6:21088.

4. Tan S, et al. Int J Oncol. 2025 Mar;66(3):20.

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