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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-SH-1092
SH-1092

Chemical Structure : SH-1092

CAS No.:

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SH-1092 (SH1092)

货号: PC-26663Not For Human Use, Lab Use Only.

SH-1092 is a potent third generation EGFR inhibitor with IC50 of 0.96 nM and 6.1 nM for EGFR(T790M/L858R) and EGFR(WT) respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SH-1092 is a potent third generation EGFR inhibitor with IC50 of 0.96 nM and 6.1 nM for EGFR(T790M/L858R) and EGFR(WT) respectively.
SH-1092 exhibited excellent selectivity against EGFR and IGF1R/INSR.
SH-1092 exhibits potent antiproliferative bioactivity with IC50 values of 8 nM and 362 nM against H1975 and A431 cell lines.
SH-1092 displayed high metabolic stability in vitro and in vivo.

物理化学性质&存储条件

分子量 541.66
分子式 C30H35N7O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-((4-(2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)-5-methylpyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

参考文献

1. Liu K, et al. Bioorg Chem. 2026 Apr 17;176:109884.

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