JIN-A02

Chemical Structure : JIN-A02

加入收藏

货号: PC-26083Not For Human Use, Lab Use Only.

JIN-A02 is a potent, mutant-selective, orally available fourth-generation EGFR tyrosine kinase inhibitor (EGFR-TKI), overcomes C797S-mediated resistance.

规格	价格	库存	数量

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JIN-A02 is a potent, mutant-selective, orally available fourth-generation EGFR tyrosine kinase inhibitor (EGFR-TKI), overcomes C797S-mediated resistance.
JIN-A02 exhibits potent antiproliferative activity against a panel of Ba/F3 cell lines harboring clinically relevant EGFR mutations with IC90 of 117 nM (EGFR_E19del/C797S), 231 nM (EGFR_L858R/C797S), 192 nM (EGFR_E19del/T790M/C797S), and 359 nM (EGFR_L858R/T790M/C797S).
JIN-A02 demonstrates potent antiproliferative activity in preclinical NSCLC models harboring EGFR_C797S and T790M mutations, with superior inhibition of EGFR signaling compared to osimertinib.
JIN-A02 elicited substantial tumor regression, indicating robust in vivo efficacy in both subcutaneous and orthotopic intracranial xenograft NSCLC models.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Lee EJ, et al. Clin Cancer Res. 2026 Feb 6. doi: 10.1158/1078-0432.CCR-25-3720.

JIN-A02

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JIN-A02

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.