| Cat. No. |
Product Name |
Information |
| PC-26580 |
INCB191358
DGKα/ζ inhibitor
|
INCB191358 is a potent, selective, and orally bioavailable dual DGKα/ζ inhibitor with IC50 of 0.12/0.36 nM respectively, shows good selectivity over Type I DGK isoforms. |
| PC-24317 |
ASP1570
DGKζ inhibitor
|
ASP1570 (Alcudacigib) is a potent, selective diacylglycerol kinase ζ (DGK zeta, DGKζ) inhibitor. |
| PC-24168 |
Pasodacigib
DGKα inhibitor
|
Pasodacigib (BAY2862789, BAY-2862789) is a potent, selective diacylglycerol kinase alpha (DGKα) inhibitor with antineoplastic activity. |
| PC-21532 |
BMS-332
Dual DGKα/ζ inhibitor
|
BMS-332 (BMS332) is a potent, selective dual DGKα/ζ inhibitor with IC50 of 9/8 nM respectively. |
| PC-21287 |
BMS-684
DGKα inhibitor
|
BMS-684 (BMS684) is a potent, selective inhibitor of diacylglycerol kinase α (DGKα) with IC50 of 15 nM, weakly inhibist DGKβ and DGKγ, does not inhibit other DGK lipid kinases. |
| PC-21185 |
Atractylenolide II
DGKQ activator
|
Atractylenolide II (AT II, Asterolide) is a sesquiterpen enatural compound with anti-proliferative activity, also is a potent, specific allosteric activator of diacylglycerol kinase family member DGKQ (binding KD=1.75 uM, MST assay). |
| PC-20914 |
BMS-502
Dual DGKα/ζ inhibitor
|
BMS-502 (BMS502) is a potent, selective dual diacylglycerol kinases alpha and zeta (DGKα and DGKζ) inhibitor with IC5 of 4.6 anbd 2.1 nM, repspectively. |
| PC-20666 |
BAY 2965501
DGK zeta inhibitor
|
Veludacigib (BAY2965501) is a potent selective inhibitor of diacylglycerol kinases zeta (DGKζ), restores T-cell cellular DAG level and induces pERK activation in anergic T-cells via DGK inhibition to assist T-cell mediate tumor cell kill. |
| PC-38842 |
JNJ-3790339
DGKα inhibitor
|
JNJ-3790339 is a potent and selective inhibitor of diacylglycerol kinase α (DGKα), demonstrates similar cytotoxicity in GBM and melanoma cells as ritanserin. |
| PC-63497 |
CU-3
DGKα inhibitor
|
CU-3 (DGKα inhibitor CU-3) is a is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region. |
| PC-70275 |
R59949
DGK inhibitor
|
R59949 is a small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets. |
| PC-70274 |
R59022
DGK inhibitor
|
R59022 (R 59-022) is a small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets. |
