BMS-684 | DGKα inhibitor | Probechem Biochemicals

Chemical Structure : BMS-684

CAS No.: 313552-29-3

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BMS-684 (BMS684)

货号: PC-21287Not For Human Use, Lab Use Only.

BMS-684 (BMS684) is a potent, selective inhibitor of diacylglycerol kinase α (DGKα) with IC50 of 15 nM, weakly inhibist DGKβ and DGKγ, does not inhibit other DGK lipid kinases.

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1 mg	￥1480	In stock
5 mg	￥3280	In stock
10 mg	￥5280	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

BMS-684 (BMS684) is a potent, selective inhibitor of diacylglycerol kinase α (DGKα) with IC50 of 15 nM, weakly inhibist DGKβ and DGKγ, does not inhibit other DGK lipid kinases.
BMS-684 exhibits a dose-dependent potentiation of IL-2 production with EC5 of 5.43 uM.
BMS-684 does not induce a T cell response in the absence of TCR stimulation.
BMS-684 exhibits the hallmark phenotype of a candidate intracellular T cell checkpoint inhibitor.
BMS-684 induces translocation of DGKα to the membrane in T cells with EC50 of 0.54 uM in the YFP-DGKα high-content translocation assays.

物理化学性质&存储条件

分子量	454.53
分子式	C27H26N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-benzhydrylpiperazin-1-yl)-1-methyl-3-nitroquinolin-2(1H)-one

参考文献

1. Wichroski M, et al. Sci Transl Med. 2023 Oct 25;15(719):eadh1892.

BMS-684 (BMS684)

生物&药学活性

物理化学性质&存储条件

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BMS-684 (BMS684)

生物&药学活性

物理化学性质&存储条件

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