Atractylenolide II | DGKQ activator | Probechem Biochemicals

Chemical Structure : Atractylenolide II

CAS No.: 73069-14-4

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Atractylenolide II (Asterolide)

货号: PC-21185Not For Human Use, Lab Use Only.

Atractylenolide II (AT II, Asterolide) is a sesquiterpen enatural compound with anti-proliferative activity, also is a potent, specific allosteric activator of diacylglycerol kinase family member DGKQ (binding KD=1.75 uM, MST assay).

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10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg	￥2280	In stock
250 mg		Get quote

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生物&药学活性

Atractylenolide II (AT II, Asterolide) is a sesquiterpen enatural compound with anti-proliferative activity, also is a potent, specific allosteric activator of diacylglycerol kinase family member DGKQ (binding KD=1.75 uM, MST assay).
Atractylenolide II is an inhibitor of the sn-1,2-DAG-PKCε pathway.
Atractylenolide II improves obesity-induced hyperlipidemia, hepatic steatosis, and insulin resistance, inhibits gluconeogenesis and promotes glycogen synthesis through the insulin-sensitive IRS1-PI3K-AKT pathway.
Atractylenolide II improves insulin resistance and hepatic steatosis in ob/ob or DIO mice by inhibiting gluconeogenesis and increasing hepatic glycogen synthesis.
Atractylenolide II reduces proteolysis of DGKQ but not of DGKA, DGKE, DGKZ, and ACTB.

物理化学性质&存储条件

分子量	232.32
分子式	C15H20O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4aS,8aR,9aS)-3,8a-dimethyl-5-methylene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one

参考文献

1. Zu-Guo Zheng, et al. Cell Metab. 2023 Jan 3;35(1):101-117.e11.

Atractylenolide II (Asterolide)

生物&药学活性

物理化学性质&存储条件

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Atractylenolide II (Asterolide)

生物&药学活性

物理化学性质&存储条件

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