BMS-502 (BMS502)

Chemical Structure : BMS-502

CAS No.: 2407854-18-4

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货号: PC-20914Not For Human Use, Lab Use Only.

BMS-502 (BMS502) is a potent, selective dual diacylglycerol kinases alpha and zeta (DGKα and DGKζ) inhibitor with IC5 of 4.6 anbd 2.1 nM, repspectively.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4580	In stock
50 mg	￥7280	In stock
100 mg		Get quote

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生物&药学活性

BMS-502 (BMS502) is a potent, selective dual diacylglycerol kinases alpha and zeta (DGKα and DGKζ) inhibitor with IC5 of 4.6 anbd 2.1 nM, repspectively.
BMS-502 displays limited inhibitory activity toward the β, γ, and κ isoforms (IC50 values=0.68-4.6 uM).
BMS-502 demonstrates EC50 values of 280 and 340 nM in human whole-blood (hWB) measuring IFNγ production and phosphorylation of extracellular signal-regulated kinase (pERK), respectively.
BMS-502 inhibits proliferation of human effector CD8+ T-cells with EC50 of 65 nM, potentiates the immune response initiated by TcR activation.
BMS-502 (10 mpk, po) demonstrates dose-dependent immune stimulation in the mouse OT-1 model.

物理化学性质&存储条件

分子量	516.51
分子式	C27H22F2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-[4-[Bis(4-fluorophenyl)methyl]-1-piperazinyl]-5,6-dihydro-5-methyl-7-nitro-6-oxo-1,5-naphthyridine-2-carbonitrile

参考文献

1. Louis Chupak, et al. ACS Med Chem Lett. 2023 Jun 12;14(7):929-935.

BMS-502 (BMS502)

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物理化学性质&存储条件

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BMS-502 (BMS502)

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