CU-3 |CAS:1815598-71-0 Probechem Biochemicals

Chemical Structure : CU-3

CAS No.: 1815598-71-0

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CU-3 (DGKα inhibitor CU-3)

货号: PC-63497Not For Human Use, Lab Use Only.

CU-3 (DGKα inhibitor CU-3) is a is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region.

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10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
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生物&药学活性

CU-3 (DGKα inhibitor CU-3) is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region.
CU-3 competitively reduces the affinity of DGKα for ATP, but not diacylglycerol or phosphatidylserine, displays selectivity over other nine isozymes (IC50>7 uM).
CU-3 induces apoptosis in HepG2 hepatocellular carcinoma and HeLa cervical cancer cells while simultaneously enhancing the interleukin-2 production of Jurkat T cells.

物理化学性质&存储条件

分子量	392.462
分子式	C16H12N2O4S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[(2E)-3-(2-furyl)prop-2-enylidene]-3-[(phenylsulfonyl)amino]2-thioxo-1,3-thiazolidin-4-one

参考文献

1. Liu K, et al. J Lipid Res. 2016 Mar;57(3):368-79.

CU-3 (DGKα inhibitor CU-3)

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物理化学性质&存储条件

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CU-3 (DGKα inhibitor CU-3)

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