R 59022 |CAS:93076-89-2 Probechem Biochemicals

Chemical Structure : R 59022

CAS No.: 93076-89-2

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R 59022 (R 59-022;R59022)

货号: PC-70274Not For Human Use, Lab Use Only.

R 59022 is a small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

R 59022 is a small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets.
R 59022 concomitantly stimulates PKC activity, selectively suppresses U46619-induced enhancement of mouse portal vein contraction under high glucose conditions.
R 59022 also induces caspase-mediated apoptosis in glioblastoma cells and in other cancers, but lacks toxicity in noncancerous cells.

物理化学性质&存储条件

分子量	459.58
分子式	C27H26FN3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

参考文献

1. Dominguez CL, et al. Cancer Discov. 2013 Jul;3(7):782-97.

2. de Chaffoy de Courcelles DC, et al. J Biol Chem. 1985 Dec 15;260(29):15762-70.

3. Nunn DL, et al. Biochem J. 1987 May 1;243(3):809-13.

4. Nobe K, et al. Br J Pharmacol. 2004 Sep;143(1):166-78.

R 59022 (R 59-022;R59022)

生物&药学活性

物理化学性质&存储条件

参考文献

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R 59022 (R 59-022;R59022)

生物&药学活性

物理化学性质&存储条件

参考文献

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