| Cat. No. |
Product Name |
Information |
| PC-38339 |
DF2593A
C5aR inhibitor
|
DF2593A (DF 2593A) is a potent, selective, noncompetitive allosteric inhibitor of C5aR with IC50 of 5 nM (C5a-induced human PMN migration inhibition), and rat and mouse orthologs (IC50=6.0 nM and IC50=1.0 nM, respectively). |
| PC-38338 |
DF3016A
C5aR inhibitor
|
DF3016A (DF 3016A) is a potent and selective C5aR inhibitor with IC50 of 50 nM (C5a-induced human PMN migration and IC50 of 45 and 37 nM against rat and mouse C5aR, respectively. |
| PC-36148 |
LNP023
Factor B inhibitor
|
Iptacopan (LNP023) is a highly potent, reversible, selective inhibitor of factor B (IC50=10 nM), the proteolytically active component of the C3 and C5 convertases. |
| PC-35445 |
Danicopan
Factor D inhibitor
|
Danicopan (ACH-4471, ALXN2040) is a potent, selective, reversible small-molecule inhibitor complement factor D with Kd of 0.54 nM. |
| PC-35224 |
PMX53
C5aR inhibitor
|
PMX53 (Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)) is a potent C5a receptor (CD88) antagonist with IC50 of 20 nM, also is an agonist for Mas-related gene 2 (MrgX2) in human mast cells. |
| PC-62226 |
Factor D inhibitor 6
Factor D inhibitor
|
Factor D inhibitor 6 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 30 nM. |
| PC-62225 |
Factor D inhibitor 7
Factor D inhibitor
|
Factor D inhibitor 7 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 50 nM. |
| PC-61821 |
NDT9513727
C5aR inhibitor
|
NDT 9513727 is a potent, selective and orally bioavailable C5a receptor inverse agonist with IC50 of 11.6 nM in radioligand binding assay. |
| PC-61772 |
BR111
C3aR inhibitor
|
BR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85 nM (inhibition of hC3a induced Ca2+ release on human macrophages). |
| PC-61771 |
BR103
C3aR inhibitor
|
BR103 is a potent, metabolically stable and highly selective small molecule agonist of complement C3a receptor (C3aR) with EC50 of 22 nM. |
| PC-60789 |
SB 290157
C3aR inhibitor
|
SB-290157 (SB 290157) potent, selective nonpeptide antagonist of anaphylatoxin C3a receptor (C3aR) with IC50 of 200 nM. |
| PC-60245 |
Avacopan
C5aR inhibitor
|
Avacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM. |
