DF3016A |CAS:2351103-44-9 Probechem Biochemicals

Chemical Structure : DF3016A

加入收藏

DF3016A (DF 3016A)

货号: PC-38338Not For Human Use, Lab Use Only.

DF3016A (DF 3016A) is a potent and selective C5aR inhibitor with IC50 of 50 nM (C5a-induced human PMN migration and IC50 of 45 and 37 nM against rat and mouse C5aR, respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DF3016A (DF 3016A) is a potent and selective C5aR inhibitor with IC50 of 50 nM (C5a-induced human PMN migration and IC50 of 45 and 37 nM against rat and mouse C5aR, respectively.
DF3016A exhibited a high degree of selectivity with no effect on PMN migration induced by other leukocyte activators such as CXCL8, CXCL1, CCL3, fMLP, CXCL12, and on LPS-induced PGE2 accumulation at 10 uM.
DF3016A protects neuronal viability by restoring intracellular calcium levels, thus opposing the increase in pro-inflammatory cytokine levels and miR-181 expression in rat model of neuroinflammatory injury.
DF3016A also inhibits osteoclast degradation activity through inhibition of C5aR signal transduction and transcription.

物理化学性质&存储条件

分子量	362.31
分子式	C13H10F3N6NaS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 1 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium (R)-5-(1-(4-((4-(trifluoromethyl)thiazol-2-yl)amino)phenyl)ethyl)tetrazol-1-ide

参考文献

1. Rosa D'Angelo, et al. Biomed Pharmacother. 2020 Mar;123:109764.

2. Laura Brandolini, et al. Neurotox Res. 2019 Jul;36(1):163-174.

3. Grannonico M, et al. Brain Res. 2020 Dec 1;1748:147057.

DF3016A (DF 3016A)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

DF3016A (DF 3016A)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.