Factor D inhibitor 6 |CAS:1386455-51-1 Probechem Biochemicals

Chemical Structure : Factor D inhibitor 6

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Factor D inhibitor 6

货号: PC-62226Not For Human Use, Lab Use Only.

Factor D inhibitor 6 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 30 nM.

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100 mg		Get quote

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生物&药学活性

Factor D inhibitor 6 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 30 nM.
Factor D inhibitor 6 is highly selective for human FD, showing no inhibition of factor B; efficiently block alternative pathway activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes.
Factor D inhibitor 6 inhibits lipopolysaccharide-induced AP activation in FD-humanized mice.

物理化学性质&存储条件

分子量	484.916
分子式	C23H22ClFN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-((1R,3S,5R)-3-(((R)-1-(3-chloro-2-fluorophenyl)ethyl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

参考文献

1. Maibaum J, et al. Nat Chem Biol. 2016 Dec;12(12):1105-1110.