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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Complement System-BM213
BM213

Chemical Structure : BM213

CAS No.: 2891606-02-1

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BM213 (BM-213, Ac-FKPLAAaR-OH)

货号: PC-72000Not For Human Use, Lab Use Only.

BM213 (BM-213) is a potent, selective and stable peptide C5aR1 agonist with EC50 of 59 nM.

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10 mg ￥1780 In stock
25 mg ￥2980 In stock
50 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BM213 (BM-213) is a potent, selective and stable peptide C5aR1 agonist with EC50 of 59 nM.
BM213 displays no C5aR2 activity and over 1000-fold selectivity for C5aR1 over C3aR.
BM213 induces C5aR1-mediated calcium mobilization and pERK1/2 signaling but not β-arrestin recruitment.
BM213 is functionally similar to C5a in human macrophage cytokine release assays and in a murine in vivo neutrophil mobilization assay.
BM213 shows antitumor activity in a mouse model of mammary carcinoma.

物理化学性质&存储条件

分子量 915.09
分子式 C43H70N12O10
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

50 mM in H2O (45.7 mh/mL)
Chemical Name/SMILES

acetyl-L-phenylalanyl-L-lysyl-L-prolyl-L-leucyl-L-alanyl-L-alanyl-D-alanyl-L-arginine

参考文献

1. Declan M Gorman, et al. J Med Chem. 2021 Nov 25;64(22):16598-16608.

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