C3aR antagonist JR14a | C3aR antagonist | Probechem Biochemicals

Chemical Structure : C3aR antagonist JR14a

CAS No.: 2411440-41-8

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C3aR antagonist JR14a (JR14a)

货号: PC-72006Not For Human Use, Lab Use Only.

C3aR antagonist JR14a is a potent and selective antagonist of human Complement C3a receptor (hC3aR) with IC50 of 10 nM (Inhibition of intracellular Ca2+ release induced by 100 nM C3a).

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5780	In stock
100 mg		Get quote

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生物&药学活性

C3aR antagonist JR14a is a potent and selective antagonist of human Complement C3a receptor (hC3aR) with IC50 of 10 nM (Inhibition of intracellular Ca2+ release induced by 100 nM C3a).
JR14a shows no agonist activity against hC3aR and 100-fold more potent than SB290157 (Cat. PC-60789).
JR14a inhibited β-hexosaminidase secretion (IC50=8 nM) from human LAD2 mast cells degranulated by 100 nM C3a.
JR14a demonstarted anti-inflammatory activity against agonist-induced paw edema in male Wistar rats.

物理化学性质&存储条件

分子量	533.468
分子式	C25H26Cl2N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-(bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-L-arginine

参考文献

1. Jessica A Rowley, et al. J Med Chem. 2020 Jan 23;63(2):529-541.

C3aR antagonist JR14a (JR14a)

生物&药学活性

物理化学性质&存储条件

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C3aR antagonist JR14a (JR14a)

生物&药学活性

物理化学性质&存储条件

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