DF2593A |CAS:2351103-43-8 Probechem Biochemicals

Chemical Structure : DF2593A

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DF2593A (DF 2593A)

货号: PC-38339Not For Human Use, Lab Use Only.

DF2593A (DF 2593A) is a potent, selective, noncompetitive allosteric inhibitor of C5aR with IC50 of 5 nM (C5a-induced human PMN migration inhibition), and rat and mouse orthologs (IC50=6.0 nM and IC50=1.0 nM, respectively).

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生物&药学活性

DF2593A (DF 2593A) is a potent, selective, noncompetitive allosteric inhibitor of C5aR with IC50 of 5 nM (C5a-induced human PMN migration inhibition), and rat and mouse orthologs (IC50=6.0 nM and IC50=1.0 nM, respectively).
DF2593A dispalys >1,000-fold selective versus other chemoattractants, including CXCL8 and CXCL1 (CI50>10 uM), as well as on a panel of different GPCRs and ion channels.
DF2593A demonstrated antinociceptive effects in several models of inflammatory pain and effectively inhibited articular hyperalgesia in CFA-induced mechanical and thermal hyperalgesia and arthritic nociception.

物理化学性质&存储条件

分子量	458.921
分子式	C18H26ClF3N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (4.9 mg/mL)
Chemical Name/SMILES	1-(4-oxo-4-{[(1R)-1-{4-[(trifluoromethanesulfonyl)oxy]phenyl}ethyl]amino}butyl)piperidin-1-ium chloride

参考文献

1. Moriconi A, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16937-42.

2. D'Angelo R, et al. Biomed Pharmacother. 2020 Mar;123:109764.

3. Li XX, et al. Biochem Pharmacol. 2020 Oct;180:114156.

DF2593A (DF 2593A)

生物&药学活性

物理化学性质&存储条件

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DF2593A (DF 2593A)

生物&药学活性

物理化学性质&存储条件

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