PMX53 | C5aR inhibitor | Probechem Biochemicals

Chemical Structure : PMX53

CAS No.: 219639-75-5

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PMX53 (PMX 53, Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg))

货号: PC-35224Not For Human Use, Lab Use Only.

PMX53 (Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)) is a potent C5a receptor (CD88) antagonist with IC50 of 20 nM, also is an agonist for Mas-related gene 2 (MrgX2) in human mast cells.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

PMX53 (Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)) is a potent C5a receptor (CD88) antagonist with IC50 of 20 nM, also is an agonist for Mas-related gene 2 (MrgX2) in human mast cells.
PMX-53 (10 nM) inhibited C5a-induced Ca(2+) mobilization in HMC-1 cells, but at higher concentrations (>30 nM) it caused degranulation in LAD2 mast cells, CD34(+) cell-derived mast cells, and RBL-2H3 cells stably expressing MrgX2.
PMX53 inhibits zymosan-, carrageenan-, LPS- and antigen-induced hypernociception in rats.

物理化学性质&存储条件

分子量	896.1
分子式	C47H65N11O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)

参考文献

1. Ting E, et al. Br J Pharmacol. 2008 Mar;153(5):1043-53.

2. Subramanian H, et al. Mol Pharmacol. 2011 Jun;79(6):1005-13.

3. Liu H, et al. Nat Struct Mol Biol. 2018 Jun;25(6):472-481.

4. Finch AM, et al. J Med Chem. 1999 Jun 3;42(11):1965-74.

PMX53 (PMX 53, Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg))

生物&药学活性

物理化学性质&存储条件

参考文献

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PMX53 (PMX 53, Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg))

生物&药学活性

物理化学性质&存储条件

参考文献

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