| Cat. No. |
Product Name |
Information |
| PC-42348 |
ZM-447439
Aurora A/B inhibitor
|
ZM-447439 is a potent, selective dual Aurora A and Aurora B inhibitor with IC50 of 110 and 130 nM, respectively. |
| PC-42868 |
Hesperadin
Aurora B inhibitor
|
Hesperadin is a small molecule Aurora B inhibitor (IC50=250 nM) that perturbs mitosis and induces polyploidy, causes mammalian cells to enter anaphase in the presence of monooriented chromosomes. |
| PC-42864 |
CCT129202
Aurora Kinase inhibitor
|
CCT129202 is a potent, selective, ATP-competitive pan-Aurora kinase inhibitor with IC50 of 42, 198 and 227 nM for Aurora A, Aurora B and Aurora C, respectively. |
| PC-42820 |
SNS-314
Aurora Kinase inhibitor
|
SNS-314 is a potent, selective pan-Aurora kinase inhibitor with IC50 of 9 and 31 nM for Aurora A and Aurora B, repectively. |
| PC-62560 |
AS 703569
Aurora kinases inhibitor
|
Cenisertib (AS 703569;R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM). |
| PC-61954 |
BPR1K653 hydrochloride
Aurora A/B inhibitor
|
BPR1K653 hydrochloride isa potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively. |
| PC-61953 |
BPR1K653
Aurora A/B inhibitor
|
BPR1K653 is a novel potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively. |
| PC-61353 |
AKI-603
Aurora A inhibitor
|
A novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent. |
| PC-61195 |
BRD-7880
Aurora B/C inhibitor
|
BRD-7880 (BRD7880) potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively, with less activity against Aurora A (IC50>2 uM). |
| PC-61110 |
SA16
PDK1/Aurora A inhibitor
|
SA16 is a potent, dual PDK1 and Aurora kinase A inhibitor with IC50 of 416 and 35 nM, respectively. |
| PC-60347 |
AKCI
AURKC-IκBα inhibitor
|
AKCI is a small-molecule inhibitor that blocks the Aurora C/IκBα interaction (IC50=24.9 uM) and exerts antitumor activity in MDA-MB-231 breast cancer cells. |
| PC-42424 |
MLN8054
Aurora A inhibitor
|
MLN8054 is a potent, selective, ATP-competitive, orally active Aurora A kinase inhibitor with IC50 of 4 nM. |
