MK-5108 |CAS:1010085-13-8 Probechem Biochemicals

Chemical Structure : MK-5108

CAS No.: 1010085-13-8

加入收藏

MK-5108 (MK 5108;VX-689;VX 689;MK5108;VX689)

货号: PC-43431Not For Human Use, Lab Use Only.

MK-5108 (VX-689) is a potent, highly selective Aurora-A kinase inhibitor with IC50 of 0.064 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg	￥5480	In stock
250 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MK-5108 (VX-689) is a potent, highly selective Aurora-A kinase inhibitor with IC50 of 0.064 nM, displays robust selectivity against Aurora-B (220-fold) and Aurora-C (190-fold) in the biochemical assays.
MK-5108 (VX-689) also exhibits high selectivity for Aurora-A over a panel of 233 kinases, only one kinase (TrkA) with <100-fold selectivity.
MK-5108 (VX-689) inhibits the growth of multiple human cancer cell lines in vitro and in human cancer xenograft models.
MK-5108 (VX-689) MK-5108 significantly enhanced the efficacy of docetaxel without increasing its toxicity.

物理化学性质&存储条件

分子量	461.94
分子式	C22H21ClFN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 6.4 mg/mL (Need warming)
Chemical Name/SMILES	Cyclohexanecarboxylic acid, 4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-, trans-

参考文献

1. Shimomura T, et al. Mol Cancer Ther. 2010 Jan;9(1):157-66.

2. Kretzner L, et al. Cancer Res. 2011 Jun 1;71(11):3912-20.

3. Shan W, et al. Clin Cancer Res. 2012 Jun 15;18(12):3352-65.

4. Chefetz I, et al. Cell Cycle. 2011 Jul 1;10(13):2206-14.

MK-5108 (MK 5108;VX-689;VX 689;MK5108;VX689)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MK-5108 (MK 5108;VX-689;VX 689;MK5108;VX689)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.