| Cat. No. |
Product Name |
Information |
| PC-42912 |
TAK-901
Multikinase inhibitor
|
TAK-901 is a multikinase inhibitor with IC50 of 21 nM and 15 nM for Aurora A/TPX2 and Aurora B/INCENP respectively. |
| PC-42409 |
Tozasertib
Aurora kinases inhibitor
|
Tozasertib (MK-0457, VX-680) is a highly potent, selective and reversible Aurora kinase inhibitor with Ki of 0.6, 18 and 4.6 nM for Aurora A, B and C, respectively. |
| PC-24004 |
AAPK-25
DLGAP5 inhibitor
|
AAPK-25 is a small molecule inhibitor of DLGAP5 with a binding energy of −9.2 Kcal/mol, suppresses proliferation of PRAD cells via inhibiting DLGAP5/E2F1 axis, also is a potent, dual Aurora/PLK coinhibitor. |
| PC-22868 |
MK-8745
Aurora A inhibitor
|
MK-8745 (MK8745) a potent, specific Aurora kinase A (Aurora A, AURKA) inhibitor with IC50 of 0.6 nM, induces apoptotic cell death in a p53-dependent manner. |
| PC-22459 |
AurkinA
Aurora A inhibitor
|
AurkinA (Aurkin A) is a chemical inhibitor of the AURKA-TPX2 interaction and potent allosteric inhibitor of Aurora A (AURKA), shows binding affinity to AURKA with ITC Kd of 3.77 uM. |
| PC-22152 |
JAB-2485
Aurora A inhibitor
|
JAB-2485 is a potent, highly selective small-molecule Aurora kinase A (AURKA) inhibitor with IC50 of 0.33 nM, with >1500-fold selectivity over AURKB and AURKC. |
| PC-22139 |
6K465
Aurora A inhibitor
|
6K465 is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC. |
| PC-21560 |
Reversine
Aurora Kinase inhibitor
|
Reversine is a potent, ATP-competitive Aurora kinases inhibitor with IC50 of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively. |
| PC-21147 |
Ilorasertib
Aurora Kinase inhibitor
|
Ilorasertib (ABT-348) is a potent inhibitor of Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases (Aur B IC50=2 nM, PDGFRβ IC50=3 nM). |
| PC-42340 |
AZD1152-HQPA
|
The active product of AZD1152, a potent, selective inhibitor of Aurora B kinase with IC50 of 0.37 nM. |
| PC-45948 |
Aurora A-IN-10
|
A potent, highly selective Aurora A inhibitor with IC50 of 3.4 nM. |
