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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Aurora Kinase-Barasertib
Barasertib

Chemical Structure : Barasertib

CAS No.: 722543-31-9

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Barasertib (AZD-1152;AZD1152)

货号: PC-42342Not For Human Use, Lab Use Only.

Barasertib (AZD1152) is a potent, highly selective Aurora B inhibitor with IC50 of 0.37 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Barasertib (AZD1152) is a potent, highly selective Aurora B inhibitor with IC50 of 0.37 nM.
Barasertib (AZD1152) displays >1,000-fold selectivity over Aurora B kinase.
Barasertib (AZD1152) induces growth arrest and apoptosis in human acute leukemia cells in vitro and in vivo.

物理化学性质&存储条件

分子量 587.5398
分子式 C26H31FN7O6P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 33 mg/mL
Chemical Name/SMILES

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-

参考文献

1. Mortlock AA, et al. J Med Chem. 2007 May 3;50(9):2213-24.

2. Yang J, et al. Blood. 2007 Sep 15;110(6):2034-40.

3. Wilkinson RW, et al. Clin Cancer Res. 2007 Jun 15;13(12):3682-8.et al.

4. Evans RP, et al. Br J Haematol. 2008 Feb;140(3):295-302.

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