Tozasertib |CAS:639089-54-6 Probechem Biochemicals

Chemical Structure : Tozasertib

CAS No.: 639089-54-6

加入收藏

Tozasertib (MK-0457;VX-680;MK0457;VX680;VX 680;MK 0457)

货号: PC-42409Not For Human Use, Lab Use Only.

Tozasertib (MK-0457, VX-680) is a highly potent, selective and reversible Aurora kinase inhibitor with Ki of 0.6, 18 and 4.6 nM for Aurora A, B and C, respectively.

规格	价格	库存
50 mg	￥1280	In stock
100 mg	￥1980	In stock
250 mg	￥3280	In stock
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Tozasertib (MK-0457, VX-680) is a highly potent, selective and reversible Aurora kinase inhibitor with Ki of 0.6, 18 and 4.6 nM for Aurora A, B and C, respectively.
Tozasertib (MK-0457, VX-680) also inhibits the imatinib-resistant ABL(T315I) kinase with Kd of 5 nM, displays >100-fold selectivity for the Aurora-A kinase over 55 other kinases with the only exception FLT-3 (Ki=30 nM).
Tozasertib (MK-0457, VX-680) blocks cell-cycle progression and induces apoptosis in a diverse range of human tumor types.
Tozasertib (MK-0457, VX-680) causes profound inhibition of tumor growth in a variety of in vivo xenograft models.

物理化学性质&存储条件

分子量	464.5864
分子式	C23H28N8OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclopropanecarboxamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-

参考文献

1. Harrington EA, et al. Nat Med. 2004 Mar;10(3):262-7.

2. Young MA, et al. Cancer Res. 2006 Jan 15;66(2):1007-14.

3. Carter TA, et al. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11011-6.

4. Giles FJ, et al. Blood. 2007 Jan 15;109(2):500-2.

Tozasertib (MK-0457;VX-680;MK0457;VX680;VX 680;MK 0457)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Tozasertib (MK-0457;VX-680;MK0457;VX680;VX 680;MK 0457)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.