PHA-680632 |CAS:398493-79-3 Probechem Biochemicals

Chemical Structure : PHA-680632

CAS No.: 398493-79-3

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PHA-680632 (PHA680632;PHA 680632)

货号: PC-42420Not For Human Use, Lab Use Only.

PHA-680632 is a potent, highly selective Aurora kinase inhibitor with IC50 of 27, 135 and 120 nM for Aurora A, B and C, respectively.

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10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

PHA-680632 is a potent, highly selective Aurora kinase inhibitor with IC50 of 27, 135 and 120 nM for Aurora A, B and C, respectively.
PHA-680632 exhibits at least 30- to 200-fold selectivity against a panel of 22 kinases compared with Aurora A.
PHA-680632 has potent antiproliferative activity in a wide range of cancer cell types (IC50=0.06-7.15 uM).
PHA-680632 shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses.

物理化学性质&存储条件

分子量	501.6232
分子式	C28H35N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(2,6-diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]-

参考文献

1. Soncini C, et al. Clin Cancer Res. 2006 Jul 1;12(13):4080-9.

2. Tao Y, et al. Br J Cancer. 2007 Dec 17;97(12):1664-72.

3. Ratushny V, et al. Oncogene. 2012 Mar 8;31(10):1217-27.

PHA-680632 (PHA680632;PHA 680632)

生物&药学活性

物理化学性质&存储条件

参考文献

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PHA-680632 (PHA680632;PHA 680632)

生物&药学活性

物理化学性质&存储条件

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